What Are the Benefits of Pharmaceutical Contract Manufacturing
Pharmaceutical Manufacturing

What Are the Benefits of Pharmaceutical Contract Manufacturing?

Contract manufacturing organizations offer various manufacturing services to the pharmaceutical and biotechnology industries. Right from drug development to full-scale production, they can help you. These pharma organizations can help manufacture a small number of materials for R&D purposes, then some more for clinical studies, and ultimately for full-scale production.

As per the 2012 Informa report named “The CMO Market Outlook to 2017”, the global spending on contract manufacturing touched the US $31.9 billion in 2011. The CMO industry has encountered double-digit growth in the past two decades, and that trend is projected to last for the next five years.

Benefits of Pharmaceutical Contract Manufacturing

Some of the benefits of pharmaceutical contract manufacturing are discussed below:

  • Advanced Skills
    • Bringing a new drug to the market quickly at affordable rates requires considerable investments in the manufacturing process. Due to the demand in the pharmaceutical industry, the use of advanced technologies and skills for manufacturing has become imperative. Even the biggest pharmaceutical companies find it challenging to have such expertise and resources.
    • CMOs have already established expertise and WHO-GMP-certified facilities to manufacture at full scale. They have strong connections with the raw material suppliers and have included various efficiency methods to produce at the lowest possible operational expense.
  • Global Presence
    • A pharma company can enter into new markets with the help of a CMO at minimal financial risks. No local investment is required in the capital, time, and executive talent areas. In some cases, the CMO may also take care of marketing and sales for its clients. Entering into new markets via joint ventures and FDI exposes an organization to financial and political risks. Pharmaceutical contract manufacturers can help such organizations in minimizing these kinds of risks.
  • Cost-effectiveness
    • The development of a new drug requires a substantial initial investment and comprehensive research. After making a massive investment in R&D, more investment is required for setting up a manufacturing facility. A company can save on extensive labor costs such as training, wages, and fringe benefits through contract manufacturing. On the other hand, a CMO has an already established market reputation and infrastructure to produce the drug at much cheaper rates.
  • Quality Assurance
    • CMOs have a pre-established drug quality check process in place that has been improved over the past couple of years. They have been manufacturing in compliance with numerous standards used in different countries and have specific systems to control the quality of the end product. CMO helps small companies utilize such quality control procedures to ensure compliance with diverse quality standards worldwide.

JoinHub Pharma – Pharmaceutical Contract Manufacturer

JoinHub Pharma is a Pharmaceutical Contract Manufacturing Company established and initiated with an aim to offer the best quality medicines at affordable rates. GMP quality assurance procedures ensure optimal performance of all pharma products. By using the latest equipment, the automated and modern pharmaceutical drug manufacturing process has been set. We offer a wide range of services with timely and reliable assistance to all our customers.

What do pharmaceutical contract manufacturers do?

Pharmaceutical contract manufacturers in India serve many purposes. They can help you relieve the burden of production off drug organizations by offering services such as:

  • Drug development
  • Manufacturing and commercial production
  • Process equipment fabrication/set up
  • Documenting FDA regulations and obtaining compliance
  • Pre-formulation
  • Stability studies/method studies
  • Pre-clinical to late-stage clinical trial material
  • Scale-up, registration batches
  • and more.

We manufacture a wide range of branded and generic medicines in almost any form. Distributors, importers, and agents are always welcome to collaborate with us and market our products in their national markets.

We produce medicines quickly at an affordable rate. Moreover, we can assist your bottom line and help you compete in the market. Get in touch with JoinHub Pharma – a reputable pharma contract manufacturing company today!

What Is the Difference Between Tablets & Capsules?
Pharmaceutical Manufacturing

What Is the Difference Between Tablets & Capsules?

Generally, there are two types of medication in finished products: capsules and tablets. Some medication can be available in both two forms. Some can only be presented in only one form.

Capsule or Tablet? It is always a mystery for both pharmaceutical manufacturing companies and consumers. For so many reasons, the debate on this topic may never be stopped.

This article will provide more details on both of these medications and see which is better for the manufacturer and consumer.

What are Tablets?

In the pharmaceutical world, a pharmaceutical tablet is a tiny dosage comprising an active ingredient that has been developed into a solid form. Tablets are generally found in a flat shape and can be broken into two pieces.  While they are usually found flat, the tablet’s shape, size, flavour, and colour can vary. This enables the manufacturer to pack the most material into a smaller space than with capsules and tends to be more cost-effective to manufacture.

Advantages of coated tablets
  • Faster in production
  • Lower raw material costs
  • Relatively smaller in volume
  • No additional quality variation
  • More diverse in sizes and shapes
  • Not restricted by supplies
  • Better stability

What is Capsule?

Capsules are typically utilized in the pharmaceutical world as vessels for both nutraceutical and pharmaceutical drugs. According to the reputed capsules manufacturing pharma company, they are very easy to manufacture, as they do not require complex formulations to produce, unlike other medicines.

Caplet is just “a small case or container.”  These capsules typically contain powder or liquid in a shell-type vessel. The usual makeup of a capsule is cylindrical and can’t be sliced in half.

Capsules have an external coating or shell that includes the active ingredients. The capsule shell is typically made from animal gelatin, even though vegan capsule options are made from starch hydroxypropyl or hydrolysate. Inside the shell is generally a powder, liquid, or paste that is the actual formulation of the API.

Capsules do not come in various sizes or shapes and tend to be popular among consumers since they are known to enter the bloodstream at the moment. There are two different types of capsules: hard capsules and soft capsules.

Advantages of hard gelatin capsules
  • Fewer ingredients
  • Low manufacturing costs
  • Less manufacturing steps
  • Flexible formula
  • Better in covering up the taste
  • Can simply separate two incompatible products
  • Consumer preferences
  • Be considered to be easier to swallow
  • More marketing possibilities

Consumer Preferences for Tablet and Capsule

As per the FDA, over 16 million people in the USA are troubled by dysphagia, and 30% of them discuss this with professionals. Around 8% of these people admit that some medications are skipped during treatment because of dysphagia, and 4% even gave up treatment.

Consumer preference is essential to the market, and it is challenging for people to accept medications that looks less appealing. Moreover, the type of preparation that is more popular with consumers will be better in sales.

Top 10 Pharma Tablets Manufacturers in India should assure the patient’s choice would not be affected since some of the medications’ physical properties (such as shape, colour, size, smell, etc.). The patient should immediately inform your doctor for replacement if there are any problems.

The Production Cost of Tablet and Capsule

The pharmaceutical industry is facing increasing research expenses and increasingly fierce market competition, especially for originator products. Its research expense can be as high as 300-400 million US dollars and require at least 5-10 years. Moreover, time and expense on market declaration, production, patent maintenance litigation have not been included.

The normal efficacy period of the patent after the listing is about 10-12 years. So for the medicine, in addition to the production expense, the production time is also vital.  Shortening the time on R&D simply means being profitable in another way.

As contrasted with tablets, fewer processing steps are involved in making capsules, which simply means lower equipment expenses, labour costs, and pollution dangers.

The investment required for capsules is much less than that needed for a tablet manufacturing pharma plant, and that it is cost-effective for operation and control and decreases inventory levels. Only when the expense of excipients is considered in isolation does the tablet process have an advantage.

Dose Control

Many people think that pharma tablets are more comfortable in dosage controlling than capsules since you can make tablets of excellent quality. Still, the dosage measuring of the medication inside the capsule is not very simple.

However, various size capsules can meet all your needs. You can add some unrevealing fillers to improve the actual quality of the medication.

Should You Manufacture Capsules or Tablets?

In conclusion, capsules are much better than tablets, or vice versa, is finally up to the consumer and which they choose. Moreover, it also depends on the tablet capsule manufacturing company to determine which is most suitable for the kind of formulation you’re looking to put into a pill form and how much you are ready to spend on this formulation to draw your potential customer’s attention.

JoinHub Pharma – The top pharma tablet manufacturer in India, offers the best quality tablets and capsules at affordable rates. Simply drop an email at [email protected] to know more about their pharma tablet and capsule manufacturing offer.

JoinHub Pharma Explains the Expectations from Third Party Pharma Manufacturing Companies in Latin America
Pharmaceutical Manufacturing

JoinHub Pharma Explains the Expectations from Third Party Pharma Manufacturing Companies in Latin America

In May, the DTAB (Drugs Technical Advisory Board) gave a green flag to the recommendation for amending the Drugs & Cosmetics Act. This makes pharmaceutical marketing firms in Latin America and the Middle East liable for any negligence in the regulations. Earlier, the company marketing substandard medicines was not held accountable for making patients consume low-quality medicines in India.

This has put immense pressure on the Pharma Marketing Companies in Latin America to go for the reliable and trusted third-party pharma manufacturing companies in India, which follow all quality standards and regulations by the FDA and other authorities.

So many times, big pharmaceutical companies get their medicines manufactured by smaller pharma companies. Today, only the manufacturer can be held responsible if something (a violation) happens (Product quality). Now, legal action can be taken against both the manufacturer marketing company.

This amendment has made pharma professionals reconsider what to expect from third-party Manufacturing pharma. Third-party manufacturing has shown tangent growth of late in most medicine production as it reduces a good amount of cost and benefits the big pharma companies.

There are numbers of third-party Pharma Manufacturing Companies in Latin America which practice quality manufacturing for drugs and follow norms. All one has to do is select the right company to avoid any sort of illegal trouble. At the same time, Pharma manufacturing in India needs to upgrade to the best manufacturing standards.

The pharmaceutical industry in Latin America has gained prominence since the 1970s, but not much attention was given to the manufacturing standards. After almost 48 years, the scenario is completely different. 9% of the pharma market is oriented, 70% is generic, and the remaining 21% is over-the-counter (OTC). To stay ahead in this highly competitive sector, the company has to put its best foot forward.

Why Do Pharma Companies Go For Third-Party Pharma Manufacturing?

Third-party pharma manufacturing is a hassle-free process that attracts many pharma marketing companies in the Middle East and Latin America. There are approximately 250 large units and almost 8,000 small scale units, which constitute the core of the pharmaceutical industry, and these companies go for third party pharma manufacturing services in Latin America because of the following reasons:

  • Pharma companies in Latin America can get time to work on the global expansion.
  • Cost-effective Manufacturing
  • Variety of Medicine to market in Industry

Third-party medicine manufacturing companies must pay special attention to the medicine’s quality at every level of manufacturing. It is pharma companies’ responsibility to utilize high-quality ingredients, chemicals for the formulations.

Experts at JoinHub Pharma have only tips for the pharma marketing company, i.e. ‘Choose the right third-party Pharma Manufacturing company in Latin America which is approved by authorities and follows the norm. One should always go the extra mile to find a reliable third-party manufacturing company that can offer the best third-party pharma manufacturing services at affordable rates.

Today, many pharma companies are looking for cost-effective and innovative ways to manufacture medicines, and third-party manufacturing is the best choice. JoinHub Pharma is one of the most trusted and reliable third-party Pharma manufacturers in Latin America and the Middle East, which is offering manufacturing of medicines at affordable rates.

In this evolving world of pharma medicine, the future of third-party pharma manufacturing is continually improving, and JoinHub Pharma plays a crucial role in keeping up with the evolving future of third-party Pharma manufacturing in Latin America and the Middle East.

About JoinHub Pharma

JoinHub Pharma is a leading third-party manufacturing Pharma company in India. The company has WHO-GMP & EUGMP Certified state-of-art manufacturing facilities at Gujarat State, India. The facilities are home to a portion of the famous branded medicines of the country.

We currently manufacture a wide range of medicines from Antibiotics, Antidiabetics, Antipsychotics, Vitamins, Antidiarrhoels, Dermatological, Antacids, to Tranquilizers, etc. utilized by people. We have also secured a good rank in the list of top 100 pharma companies in India in 2020.

The third-party manufacturing pharma products are manufactured according to the master formulation, prepared by trained staff at JoinHub Pharma, adhering to purity and elevated standards. All products are accordingly manufactured and packaged in strict accordance with good manufacturing practices. We provide quick delivery of orders.

Due to our world-class third-party manufacturing facilities, we efficiently manufacture a diverse range of drug formulations in several segments. We are fully dedicated to the quality of medicines, and thus our medicines are recommended by many licensed doctors.

If you’re looking for reliable third-party medicine manufacturing companies in Latin America, contact JoinHub Pharma. We deliver what it takes to be the top third-party manufacturing Pharma or the best Third-Party pharma manufacturer in Latin America.

Be part of one of the best and reliable third-party manufacturing pharma companies!

How Do You Choose The Right Pharmaceutical Contract Manufacturer For Your Pharma Products In Latin America
Pharmaceutical Contract Manufacturer

How Do You Choose The Right Pharmaceutical Contract Manufacturer For Your Pharma Products In Latin America?

The development of a new medicine is a complex task and requires many iteration and decisions before a commercial launch. Some biotech and pharmaceutical companies in Latin America choose to outsource most or all of their medicine manufacturing efforts throughout the development phase with a contract manufacturing organization.

However, choosing the right contract manufacturer in Latin America is crucial in pharma manufacturing to ensure product success as well as your pharma company’s performance.

Enlisting the right pharmaceutical contract manufacturing organization is a critical decision that puts your brand’s reputation, supply chain, and patient safety in someone’s hands. For the best pharma product manufacturing relationship, here’s how to choose the right contract manufacturer.

Know What You Need From Them

The first step of choosing the right contract manufacturer in Latin America is to know precisely what you need. There are various CMO relationships you can have based on your business needs. For example, a tactical contractor is ideal for a single project or to become a helping hand in in-house productions.

Working with a contract manufacturer in South Africa can allow you to establish an ongoing and long-term relationship without giving too much control over decision-making. Otherwise, a strategic partnership with a CMO is a long-term relationship between you and the CMO to accomplish defined business goals by maximizing the effectiveness of each participant’s resources.

Many pharmaceutical companies in Latin America and South Africa are looking for a reliable CMO to support their projects-right from the development phase to clinical trials and commercial pharmaceutical API manufactures and production and drug manufacturing, product formulation, and packaging. For these pharma companies, a strategic partnership is the best option.

 

Create a List of Top Contract Manufacturing Organization

Create a shortlist of top pharmaceutical Contract manufacturers you’re interested in working with, and analyze every CMO on the same characteristics and needs to single out the right partner eventually. Finding contract manufacture in Latin America is as simple as searching local CMOs or asking industry colleagues for references.

Ensure Quality and Compliance Standards

For safety and your reputation, the pharmaceutical contract manufacturing service you choose should be reliable. Make sure that they have a strong standing with regulatory agencies like the FDA and WHO. Check if they have had in past relationships for gaps in quality and consistent drug manufacturing.

Do not forget to request a report of their recent inspections, audits, and investigations. You won’t want to hire Third-Party contract manufacture in Latin America, Middle East, and South Africa that doesn’t host regular inspections and audits—or one that may be hiding their poor results. This could result in your product shipments’ drug delay or cancelation due to your contract manufacturer’s poor compliance.

Consider Their Experience and Expertise

Considering the capabilities of potential CMOs is an essential step in the process. You’ll need to determine if your pharmaceutical drug manufacturer has the capability and expertise required to manufacture your product. To do so, think about their expertise and experience. You do not want to become the trial run for your CMO, so find out about their previous experience.

Read research and reviews, ask for referrals, or consider hiring a consultant to help evaluate CMO’s profile. You must request that your CMO share key performance indicators they have in place and their success in meeting client expectations.

When evaluating their expertise, you’ll have to make sure it is in the realm of what you’re looking for. This shows they can finish similar needs. However, don’t just assume they have the right capabilities depending upon what they’ve done previously. You’ll still have to be upfront about exactly what you are looking for to make sure they meet your individual expectations and requirements.

Room for Growth

Like choosing a CMO with broad pharma manufacturing services, the pharmaceutical contract manufacturer in Latin America should provide room for growth. An ideal CMO can grow with your pharma product’s success. As such, this contract manufacture should have the proper equipment, staffing, and flexibility to handle your production cycle as it grows.

Confidentiality

The issue of confidentiality can be crucial when it comes to formulation development. A confidentiality agreement is a must-have document, and it should be draft in a way to benefit both parties. Evaluate how the potential CMO ensures confidentiality. The pharmaceutical contract manufacturer should have a system in place that limits the usage of client names or initials, locks data in a secure area, and sends separate client passwords for electronic access to documents.

There are many things to consider when choosing the right CMO in Latin America for your pharmaceutical product. Carefully assessing your needs, capabilities, reputation, the CMO’s abilities, and previous expertise is the ideal way to build a successful partnership.

 

You may also like to read these blogs:-

Best Indian Pharmaceutical Tablets Supplier in Latin America

pharmaceutical companies in Nigeria
Pharmaceutical Manufacturing

Challenges and prospects of pharma manufacture in Nigeria

Nigeria is the largest economy in Africa. It has a huge consumer market. In fact, Nigeria is considered the hotspot of the pharma industry in entire Africa. Unfortunately, the pharmaceutical companies have become victims of the recent recession.

The International Monetary Fund has decreased the GDP growth forecast of Nigeria to 1.8% in July 2016. Gathering the challenges faced by pharma manufacture in Nigeria:

  • Absence of immediate accessibility to pharmaceutical products
  • Lack of good quality of medicines
  • The extremely high price of imported medicines

The respective challenges have urged certain things related to political and public interests in Nigeria:

  • Promotion of self-sufficiency
  • Development of capacity of local industries
  • Creation of new jobs
  • Freedom of international medicine suppliers
  • Production of foreign exchange via local medicine exports

Pharmaceutical companies in Nigeria used to import dosage forms:

Majority of Nigeria’s developing countries used to import finished dosage forms till mid 20th century.

  • Tablets
  • Syrups
  • Powders
  • Suspensions
  • Creams
  • Capsules
  • Parenteral preparations
  • Suppositories
  • Ointments

There was a lack of strict focus on local production of processing equipment, necessary dosage forms, and raw materials. But, the recent days are experiencing a shift towards local production.

More than the top 20 pharmaceutical companies in Nigeria are manufacturing simple medicinal products presently. Still, large numbers of pharma products come from India, Europe, China, the USA, Brazil, Taiwan, Pakistan, and so on. Experts say that Nigeria has to go a long way in the matter of producing medicines locally and meet the health needs of the citizens.

Let’s look at the recent prospects on Nigeria:

Local government and private manufacturing laboratories and research organizations are competing with many reputed foreign companies. In fact, pharmaceutical exporters in Africa are distributing their locally produced products to other nations.

Training is being given to the pharmacists. Lots of workshops and educational programs are being held in African countries. Now, people are showing confidence in the locally manufactured medicines that are good in quality.

Now, in Nigeria, highly trained and registered pharmacists consult about analysis of drug production as well as quality assurance. They have the power to give certificates to the deserved pharmaceutical companies in Nigeria.

Presently, there are many local industries producing starches for gums, non-internal preparations, plastic containers, etc. Now, local manufacturers no longer receive certain drug excipients from other countries. The top 20 pharmaceutical companies in Nigeria are manufacturing finished products, excipient raw materials, specific dosage forms, etc. for exporting and local usage.

Nigeria is developing a comprehensive commercial model:

The leading pharma companies in Nigeria are revisiting the commercial model. They are coming up with innovative strategies for the country ensuring certain aspects.

Firstly, they are focusing on the actual ambition related to the global priorities and Nigeria’s present conditions.

Secondly, stress is being given to the main buyers and the value they can bring.

Thirdly, strategies are working on geographical conditions including districts and cities to prioritize.

Fourthly, improvement of the product portfolio is being done.

Fifthly, the experts are finding the right ways to address patients’ pain points easing their access to high quality pharmaceutical products.

Sixthly, they are researching the best sales and distribution model that can enable patients to the right healthcare solution.

Seventhly, stakeholders from local areas and international zones are taking interest in investing in Nigeria’s pharmaceutical industry. The pharma companies in Nigeria are approaching long-term partnerships with big medicine producers from India, Europe, China, etc. Extensive research is going on about the return on investment and sales growth.

Eighthly, specialist pharmacists are finding skill gaps and organizational flaws. They are planning for filling the potential gaps for the growth and development of Nigeria’s pharma industry.

Ninthly, plans are being held in order to reach milestones, targets, etc. to make the future pharma market better.

As per estimation, the Nigerian pharma market value can increase by approximately 9% each year. By the year 2026, it can reach around $3.6 billion. It will be the largest market in South Africa. Again, as per expert study and opinion, Nigeria will gain the power and capacity to contribute approximately $2.2 billion to pharmaceutical sales which will include prescription drugs and other products.

In short:

Nigeria is gradually overcoming the past and current challenges. The nation is progressing towards a strong pharmaceutical industry that can export good quality drugs at affordable prices. The pharmacists are getting training from internationally certified professionals. They are concentrating on boosting the local market so that entire Africa doesn’t have to import costly drugs from outside.

Many multinational pharma companies have set up their manufacturing units in Nigeria and are contributing a lot to increase the market capacity. Local people are given education and training so that they can be employed. People’s life is getting better as they can now avail proper healthcare at an affordable cost within the country.

Moxifloxacin Hydrochloride Eye Drops 5Mg/Ml
Pharmaceutical Manufacturing

Making the Case for Indian Generic Drug Manufacturing

American consumers are often amazed to find out about the drugs prescribed to them. For example, numerous individuals are taken aback to discover that more than 90% of the medicines prescribed by specialists in the U.S. are generics.

Considerably more surprising is the fact that in excess of 33% of these drugs were likely manufactured in India. This country’s ability to manufacture cost-effective, generic drugs has led to its reputation of being the “pharmacy of the world.” By export volume, India is presently the biggest supplier of generic medicines globally, providing 18% of global generic medicines.

It makes sense that when the media raises concerns about the safety and scope of imported and exported generic medicines, consumers question the quality of medicines fundamental to their health. Ongoing stories have depicted an industry laden with quality issues. These concerns raise fears among patients that consuming medicines made in India may bring about unpredictable effects.

Luckily, the generic medicines manufactured in India are as safe and efficacious as those produced in the United States.

In the past few years, expectations of regulatory organizations around the globe have increased. With the number of companies and manufacturing facilities supplying to the regulated market growing fast, it is natural that the agencies are increasing their efforts. Since 50% of India’s pharmaceutical exports are too highly regulated markets such as the United States, Indian manufacturers must comply with severe U.S. Food and Drug Administration (FDA) guidelines that incorporate regular and rigorous inspections to guarantee compliance.

Also, Indian manufacturers are being examined by inspectors from every market they export to — Mexico, South Korea, Germany, Japan, Brazil, to name a few — who regularly visit and assess Indian pharmaceutical factories.

In response to this growing regulatory environment, pharmaceutical companies in India keep on reinforcing their processes, while improving operating procedures, automation, and quality management systems. This incorporates vigorously proficient quality control and quality assurance systems close by workshops and training programs, building an omnipresent culture of quality. The outcome is a focus on quality that begins at a shop-floor level for machine operators, guaranteeing compliance from the ground up.

Redefining India’s reputation

So, what should be done in order to the practical steps being taken by Indian generic manufacturers to grasp a culture of high-quality? Significantly, beyond presenting a proof-based case that generics manufactured in India are efficacious and safe, we should likewise show the huge great these drugs provide to consumers.

For instance, Indian generic drug manufacturers play an important role in bringing safe, new, affordable drugs to US consumers. In 2018 alone, the FDA affirmed a record of 741 generic drugs with Indian organizations, representing almost 50% of the approvals. (Indian companies got 73 tentative approvals and a total of 415 product approvals in 2018.)

Consider that the Indian pharmaceutical industry has altogether reduced the burden on the U.S. public health system by making genuinely necessary medicines affordable and readily accessible. Every third tablet sold in the U.S. comes straight from India. Generic drug savings added up to $292.6 billion in 2018, as per the AAM Access & Savings Report (2019). Of this, expected savings adding up to $80 billion in 2017 can be credited to the contributions from Indian generic companies.

Indeed, Indian pharmaceutical companies are presently turning into a key source of medication for the rest of the developing world.

India’s global reach

The worldwide demand for medication from India will keep on going up. India’s share of the US generic market is growing quickly, and the number of organizations and manufacturing facilities supplying to the U.S. market is growing too fast. The focus on improved healthcare infrastructure, growing regulatory necessities, and surge in research and development spend bodes well for the pharma business.

This growth isn’t exclusive to India. Indian generic manufacturers are additionally producing in the U.S. and in other countries at whatever point necessary. The Indian Pharmaceutical Alliance (IPA) accounts for 23 research-based national pharmaceutical companies centered with respect to patient health and safety with a pledge to give quality drugs to patients throughout the world.

To drive forward this commitment to give high-quality and safe drugs, IPA organizations have attempted a few focused steps towards excellence in quality. Over the past 4 years, IPA has worked towards:

  • Benchmark Indian pharma drug quality with the rest of the world
  • Create targeted guidelines and best practices in areas of significant, which are vetted by regulators over the world, including the FDA
  • Expand the capabilities and skills of quality talent for Indian pharmaceutical companies

Moreover, between 2012 and 2016, IPA companies contributed $161 million to generic-drug user fees, subsequently offering more than half of the revenue under the Generic Drug User Fee Amendments, which empowers the FDA to bring more prominent predictability and timeliness to the review of generic drug applications, just as assists with funding the inspection of generic plants.

In conclusion

Indian companies will keep on expanding globally, enriching their manufacturing capabilities to fulfill the growing demand on the planet. The future will see a significant role in worldwide healthcare by Indian pharma, not only in making medicines affordable, yet in addition to reinforcing India’s position as a worldwide hub for making innovative and high-quality medicines.

By making key strategic moves in uncharted geographies, technologies, and products, Indian generic manufacturers look to recover their position as a world-class provider of affordable, excellent drugs. Guaranteeing we communicate this vision and quality-centric focus will be essential to the splendid future between manufacturers and those who depend on these medicines.

All things considered, a clear and concise understanding of our record of achievement and emphasis on quality supports the continuous efforts of Indian generic manufacturers to give quality solutions that eventually benefit consumers across the globe.

We at JoinHub Pharma offer 1000+ high-quality pharmaceutical drugs, generic medicines in India, and other countries like. Contact us today!

 

Contact us for more information:
Call : +91 9979382527
Mail us at [email protected]
Website: https://joinhubpharma.com

generic-or-organic
Pharma Products Pharmaceutical Manufacturing

Top 5 Generic Drug Makers in India

The demand for generic drugs is increasing worldwide and pharmaceutical companies are realizing the great potential this opportunity affords. Efficient and Cheap drugs are always needed, making this a growing business sector for drugmakers. The global market for generic drugs is projected to rise at a compound annual growth rate (CAGR) of 8.7 percent; meaning that, in the forecast period 2016 to 2021, the global market will increase from $352 billion to $533 billion.1
In this article, the top five generic drug makers are listed by total revenue, measured in the financial year (FY) 2018. Counting down, they are as follows

JoinHub Pharma
JoinHub Pharma is an award-winning Pharmaceutical Company in India. We hold a reputed name with regards to branded medicines and generic medicines. Our company is certified by the highest authority like WHO, FDA, ISO 9001:2008, GMP, etc. We are a top pharma manufacturer known for our top of the line quality pharma products and services. Without a doubt, we are considered to be one of the best generic medicine manufacturers in India. In fact, 85% of our revenue is generated by way of exporting to MIDDLE EAST, CIS, and AFRICA production facilities. We are popular for our widest list of medicines which contains more than 1000+ pharma products.

The range of products we manufacture are:

● Tablet, Capsules and soft gel capsules, Injection, oral liquid, external
● preparations cream, ointments, suspensions, eye ear nasal drops in different
● therapeutic expertise CNS,
● Anticonvulsant, anti-diabetic, anticancer, antibiotics, antiviral, antibacterial,
● immunosuppressants,
● hormone, nutraceutical, derma care, probiotic, prebiotic, cough,
● expectorant, NSAIDs, nephrology and urology, oral contraceptives, gynecology,
● oral health care and many more

Every manufacturing is done in our company-owned GMP-WHO certified units. What makes us best to associate with and become our client?

Here are the points for consideration:

● Latest Packaging Technology like ALU-ALU is utilized.
● Manufacturing Agreement is kept transparent through clarified terms and
● conditions. It likewise incorporates Intellectual property Rights,
● We have a reputation for updating with long term relations.
● Widest range of 1000+ pharma items
● Skilled R&D team with completely furnished automated laboratory,
● Manufacturing happens in excise duty-free zones which make the business deal moderate.
● Approved pharma products from Food & Dry Administration (FDA) for every medicine
● Approvals from DCGI and FSSAI for all products
● Units and plants certified by well-known associations including Good
● Manufacturing Products (GMP) and the World Health Organization (WHO)
● Secrecy is maintained about the generic drug product formulation with everything being equal.
● Abbreviated New Drug Application (ANDA) approval to advertise a generic drug product has been taken care of by the organization itself.

Lupin Pharmaceuticals
This pharmaceutical company is based in Mumbai, India. Lupin Pharmaceuticals is a subsidiary of Lupin Limited and one of the top five pharmaceutical companies in the country, making it a key player in the industry. The company was founded in 1968 and while its main focus is generic drugs, it also manufactures branded medications and active pharmaceutical ingredients (API).

Sun Pharmaceuticals
Sun Pharmaceuticals, also headquartered in Mumbai and has over 2,000 marketed products. According to Sun Pharmaceuticals, they have built a portfolio of about 10 specialty products, five of which are already on the market. They expect that this side of their business will be a key driver in the coming financial year.5 In addition to being a leading generic drug maker, the company also provides a range of APIs. They invest heavily in R&D, using around 7-8 percent of their annual revenues to improve this side of their business. Established in 1983, Sun Pharma sold items across India before expanding globally in 1996.

Sandoz
Sandoz is a generic and biosimilar producer division of the Novartis Group. Headquartered in Munich, Germany,10 the company merged with Ciba-Geigy in 1996 to form Novartis. According to the company, a planned transformation for Sandoz through Novartis is expected to enable them to compete effectively in a more challenging environment by increasing their share of higher-margin differentiated products. The retail generics franchise amounted to 80% of the company’s total business, followed by biopharmaceuticals (15%) and anti-infectious (5%). Sandoz also offers a variety of drug delivery mechanisms.

Teva Pharmaceutical Industries Ltd
Based in Jerusalem, Israel, Teva is the world’s leading generic drug maker; yet it’s also active in ventures that include APIs. Teva manufactured nearly 120 billion tablets with one out of nine generic prescriptions in the US containing the organization’s products. Teva says that it has a unique understanding of local markets. Founded in 1901, Teva began as a small wholesale drug business distributing imported medications. In the 1980s, it then expanded internationally and entered the US market.18 With a specialty R&D program, the company says it has a “robust pipeline” of high-value medications

Conclusion
Generic drug makers have vast potential in the market and, due to the high demand for generics, significant profits exist to return investments. Opportunities for these companies provide the potential for even greater growth in the future, with the market set to increase soon.

Call : +91 9979382527
Mail us at [email protected]
Website: https://joinhubpharma.com

vitamin C tablet manufacturer
pharmaceutical exporters Pharmaceutical Manufacturing

Best Exporters for Vitamins from India: Serving the World

The world needs more medicines at an affordable price and no country is better than India to serve them. India’s strength lies in the export of generic pharmaceuticals. The manufacturers and the government have to focus more on the production of excellent quality drugs if India has to remain ahead of China for long in the future.

Facts about best exporters for vitamins from India:

India has exported $651 million worth of pharma products to Latin America in 2016.It is bigger than China’s $404 million. In the last five years, India has gracefully beaten China in the matter of exporting pharmaceutical products to Latin America. Most importantly, India imports raw materials in bulk from China and converts them into high-quality finished products, and finally exports the products.

India is a country that exports generic drugs to other countries. So, the government of Latin America along with the citizens has a positive view of India as they think this country is a vital contributor to their objective for reducing the healthcare cost. The pharma companies of India are getting encouragement from Brazil and Chile to enter into their countries for pressurizing the MNCs and local medicine producers for boosting the availability of generics and lower the medicines’ cost.

India: An important drug supplier to foreign countries:

India is known to be a major supplier of bulk medicines, especially API to the drug manufacturers of Latin America. The worth of bulk drugs is more than $300 million. It let the drug manufacturers of Latin America to lower their production cost.

In fact, there are some pharma companies in India that have set their manufacturing plants in Argentina, Brazil, and Mexico. These units export drugs to the US and other countries along with supplying to the local medicine market. There are certain multivitamin tablet manufacturers from India that have earned respect from the global market.

The positive perspective and success of the Indian pharmaceutical industry have supported in boosting the image of other Indian organizations in Latin America. People from other industries have gained confidence on Indian products apart from medicines.

India is leading China in the matter of pharmaceutical products:

India has won over China in the export of pharmaceuticals globally. In the year 2016, the pharma exports of India were $13 billion of worth, whereas, China’s worth was only $7 billion. The most amazing fact is India stands 10th as the pharma exporter in the whole world. China is at 16th rank.

Let’s talk about other importers:

India stands 4th as a pharmaceuticals supplier to the US. The worth of exports is $5.1 billion. On the other hand, Chinese export worth to the US was just $1.1 billion. This is the fact of 2016. 30% of the generic drug import of the US occurs from India. India boasts the largest number of US FDA approved pharmaceutical units outside the US. It was over 200. Some big Indian pharmaceutical firms have successfully established their manufacturing units in the US.

The pharma firms including Vitamin C manufacturing companies in India have surpassed China in the matter of exports to the EU. In the year 2016, the worth of export from India was $1.56 billion, whereas, the worth of China’s export was $1.36 billion. The pharma exports of India in Africa were worth $2.8 billion, and China’s was only $618 million.

Do you know which country is the second-largest market for pharma exports from India? It is the UK. In 2016, its worth was $464 million. Others are Australia that stood at $220 million, France stood at $145 million, Germany stood at $161 million, Belgium stood at $125 million, Netherlands stood at $143 million, and Canada stood at $143 million.

Half of India’s total pharmaceuticals production is for export:

More than 50% of the global exports of India are covered by the rigorously-regulated western markets and the US. So, India has earned trust from other countries in terms of quality and affordability.

India- The largest exporter of generic medicines in the world:

Be it Vitamin C tablet manufacturers in India, or other medicines’ producers, around 20% of the volume of global export is covered by the pharma industry of India. The basic reasons are the low production cost and ample of human and technical resources. India has finely gained a competitive advantage in the field of generic medicine export. In this time of Corona Pandemic, the Zinc tablet manufacturers in India along with other generic drug exporters have successfully lowered the healthcare costs in developed countries such as the US, the UK, etc. Many western NGOs and other foundations purchase Indian generics for use in their healthcare activities in Africa. Overall, it can be concluded that India is the best global exporter of Vitamins and generic drugs and serving multiple countries simultaneously with high-quality drugs at affordable costs.

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pharma-manufacturer
Pharmaceutical Company Pharmaceutical Manufacturing

Five Advantages Of Pharmaceutical Manufacturer and How You Can Make Full Use of It

India is always one step ahead in the field of pharmaceutical manufacturing predominantly because of the affordable cost of production, infrastructure, and skilled workforce. These aspects have launched India among the major players in the segment of generic medicine production. Moreover, India has a vast domestic market that helps it to dominate the world as the topmost pharmaceuticals manufacturer. Overall, India is a lucrative place for the medicine company owners who wish to outsource their products.

Digging into the 5 most important advantages of pharmaceutical manufacturers in India:

  1. Extremely cost-effective:

It needs a huge amount of initial investment and thorough research to develop a new drug. First, investment is done on comprehensive research and development. Then, huge finance is needed for setting up the manufacturing units. But, when it comes to the pharmaceutical products manufacturer, especially the contract manufacturing organizations, then the tension remains much lower as they have the ready-made infrastructure and established expertise for producing medicines at cheap rates. Hence, labor costs including wages, fringe benefits, training, etc. can be substantially saved.

  1. Highly advanced technology and skills:

Currently, there is a rapid change in the rise of the pharma industry. Advanced skills and technology are obligatory for production. It needs colossal investment in the process of manufacturing to launch new drugs in the existing market quickly at the lowest possible price. There are many big names in the pharma industry that face trouble in boasting such resources and expertise. But, the best pharmaceutical companies in India that solely focus on contract manufacturing already possess such kind of expertise as well as resources to produce the needful at full scale. Their intimate connection with the raw material suppliers which adds fuel to the manufacturing segment.

  1. Good quality assured:

The dominant Indian pharmaceutical companies are always prepared with pre-established quality checks boosted for several years. The medicines are produced in consent with different standards used in various countries. These manufacturers have typical systems in assured place for controlling the end products’ quality. The contract-based manufacturing uses techniques of quality control for ensuring the acceptance of the quality control standards prevailing globally.

  1. Present throughout the world:

A pharmaceutical company can enter into a new market through a first-rated pharmaceuticals manufacturer. There is a negligible financial risk. Also, minimum local investment is enough for the workforce, capital, and time. In certain areas, manufacturing companies take control of the clients’ marketing and sales. Most importantly, various resources are needed to manufacture a drug and a particular country may not have all of them. Hence, the medicine companies of that country preferably give the contract to the best pharmaceutical companies in India where the required resources are readily available at an unimaginably low cost.

  1. Growing competition:

The price of various medicines is continuing to be low because of the intense competition and the growing number of Indian pharmaceutical companies. Refined medical infrastructure, newly emerging market, increasing diagnosis of chronic disease, the launch of patent products, etc. contribute to the growth. India can typically manage to produce drugs at low cost which also includes factors like equipment, labor, property rates, and utilities at an affordable cost.

Pharmaceutical companies all over the world are making complete use of Indian pharmaceutical manufactures due to unavoidable reasons:

  • Both are winners:

India has a favorable business model that is a reason to smile. The hubs that purely manufacture drugs can produce the same products for different pharma companies. Hence, both the manufacturing partner and pharma company will be at the winning position. Furthermore, some pharma houses give contracts of the same product to multiple manufacturing units when there is a surge in demand. It ensures an uninterrupted supply of medicines.

Expansion of business at low investment:

Yes, the manufacturers of pharmaceutical products in India have made it possible. Choosing a third party model paves the way to expand the business without the requirement of huge investment. Partnering with a company delivering the best pharma products to the customers as well as the channel partners helps in building an excellent reputation in the prevailing market.

Excellent work efficiency:

Investing in the best pharmaceutical companies in India that manufacture drugs as a third party as well as a business partner guarantees magnificent productivity and work efficiency.  The right producing hub can bestow the best value for money.

Upgraded manufacturing plants make exporting of medicines trustworthy globally:

The pharmaceutical manufacturing companies in India make significant investments in the hope of upgrading their plants for reaching and maintaining international standards. As per Deloitte’s report in 2015, Indian drug manufacturing plants have matched the unique standards set by the FDA. Hence, medicine companies from all over the world are relying on these manufacturing companies and are not minding importing medicines from India. Hence, Indian pharmaceutical manufacturers are making huge profits by exporting generic and other medicines.

Conclusion:

Better sales and higher profits combined with rich professional experience and superior quality products- Indian pharmaceutical companies can give the ultimate benefits to the entire pharma industry both in India and oversees. The medicine manufacturers are truly transforming the current healthcare system and will remain at the top in the coming years too.

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Pharmaceutical Manufacturing Uncategorized

How to control the quality parameters in pharmaceutical manufacturing?

Quality control is a fundamental operation of the pharmaceutical business. Drugs must be promoted as safe and therapeutically active formulations whose presentation is predictable and consistent. New and better medicinal agents are being produced at an accelerated rate. Simultaneously more demanding and sophisticated analytical methods are being produced for their evaluation.

Importance:
Quality control of products bears unmistakable advantages for all – regardless of whether producers or consumers. Some of the important advantages of quality control are as follows:

1. The brand products build up image goodwill which ultimately increases sales to 10X.
2. It helps the manufacturers/ entrepreneurs in fixing responsibility of workers in the production process.
3. Quality control also helps in minimizing costs by increasing efficiency, standardization, working conditions, etc.
4. It also enables the entrepreneur to know the cost of his / her product quite in advance which helps him in determining competitive prices of his product.
5. Last but not the least; the entrepreneur can confirm whether the product manufactured by him/her is in accordance with the standard set by the Government. It further facilitates the entrepreneur to take necessary actions to comply with the standard set.
3 Key approaches to quality control

Here are three key ways to help you ensure you develop a strong, patient-centric control strategy:
1. Combine control strategy with GMP
The control strategy can likewise be combined with the GMP design strategy for front-end studies. This manufactures the foundation for the conceptual design of another expansion or improvement of a production line or facility.

Actually, it is hard to propose an appropriate design without a control strategy. This is because it gives a systematic and organized way to the design, including GMP aspects and regulatory desires. Furthermore (circling back to the patient) it gives a more strong base for client decisions and decreases the risk of having to invest altogether more at a later stage – especially when it turns out to be clear which products will be manufactured in the facility or at the new line, and how.

A control strategy evolves all through the product lifecycle. It is product-specific during submission, yet after scale-up and technology transfer and not long before process performance qualification or process approval, it grasps facility, utility, equipment, process automation controls and other GMP controls.

It even incorporates business-oriented controls, including yield, overall equipment effectiveness, production lead-time, wastewater, operator protection, energy consumption, and environmental controls. Often, this control sort of strategy is called, ’Manufacturing Control Strategy’ or ‘Production Control Strategy’.

2. Put the patient first
Control strategy begins with the patient and ought to consistently be established during development with the patient in mind. A Quality by Design (QbD) is a deliberate process to produce Robust processes with the help of Quality Risk Management (ICH Q9). It is imperative to control the “Variability” of Raw materials just as in Manufacturing process by recognizing Critical Quality Attributes (CQA) / Critical Material Attributes (CMA) and Critical Process Attributes (CPP) through Risk Management process. It assists with having a better understanding of Process & Product along these lines helping Life Cycle Management of the product (LCM). It should:

• Establish a quality objective product profile with related basic quality attributes.
• Identify the material attributes and critical process parameter.
• Outline how the process ought to be worked and controlled to ensure the product is of the right quality, the expected quality target and critical attributes.
• And at last, the control strategy utilized for commercial production must be approved by healthcare specialists and reflected in the masterbatch records and standard working procedures.
Advantages of QbD to the Generic Industry
• A better understanding of the procedure and the product.
• Minimum batch failures.
• A better understanding of the dangers involved & mitigation.
• Minimising variations to accomplish consistency in manufacturing quality.
• An enhance QbD way to deal with pharmaceutical development gives chances to progressively adaptable regulatory approaches for instance: Manufacturing changes within the approved design space can be without regulatory review or approval.
• Reduction of post-endorsement submissions.
• Greater regulator confidence of powerful products.
• Innovative Process Validation methods.
• More drug accessibility and fewer reviews from the market.
• Improved yields, fewer investigations, reduced testing, lower cost, and so on.
• The timely launch of products.
• Right first time & each time concept.
• Real-time Release thru PAT implementation.
• Cost savings/ Return on investment.
• More effective technology transfers.

A patient-centric control strategy is an establishment for designing a manufacturing facility and production line. This is valid for: conceptual process and facility design studies, equipment and facility qualification, process performance qualification, defining user requirement specifications, process validation, continued (ongoing) process verification program, just as the everyday manufacturing and control program.

When is a patient-centric control strategy defined?
You should define the patient-centric control strategy during product development and process design. It should concentrate on accomplishing the right basic quality attributes by controlling critical process parameters and material critical quality attributes, frequently done on a lab scale.

When the process is scaled-up and moved to a commercial site, you ought to expand it into an operational-oriented production control strategy utilizing a cross-functional team, remembering subject matter specialists in engineering, development, technical support, quality assurance, production, automation and IT.

3. Focus on production in the control strategy
The production control strategy is exceptionally complex as it reflects process understanding. Be that as it may, if it is built up utilizing a systematic science and risk-based approach, you can utilize its full potential for other activities when increasing the facility and preparing it to produce products.

A Production control strategy to act as an input and definition for the masterbatch records, the batch execution system and the process control system. However, it is likewise valuable to define the continued ongoing process verification, for smarter and leaner qualification, for process automation projects, and validation programs, and lastly, for continual improvement activities.

A robust production control strategy, dependent on process understanding, implemented in business operation minimizes the danger of compromising product quality and process robustness. It assists to address deviations, improve in general management, and means continuous improvement can be proactively proposed. Also, improvement opportunities drive lifecycle management activities – profiting both the patient and the business.

We at JoinHub Pharma concentrate more on Quality control and Quality Assurance as these are our strengths and the key differentiators. We have EU GMP certified plants in India to guarantee that products are reliably manufactured to a quality suitable for consumers intended use.

Contact the best pharmaceutical medicine supplier today!

Pharmaceutical Manufacturing

How to choose the right pharma contract manufacturing company from India?

There is no denying that that pace and amount of contract manufacturing in the pharmaceutical industry has grown significantly over the last couple of years. There are numerous reasons why pharmaceutical companies decide to outsource or contract out their manufacturing activities. JoinHub Pharma deals in Third party pharma and contract manufacturing in India. Each and every manufacturing is done in our company-owned WHO-GMP certified units. A recent Frost and Sullivan report on outsourcing in the pharmaceutical industry referred to the following factors as some of the main reasons why pharmaceutical companies choose to outsource:

• Outsourcing can decrease overall expenses by 30% to 35%
• Faster and less expensive to have discovery work outsourced, decreases drug development cost
• Reduces problems faced during the regulatory processes around the globe
• Improves producing efficiencies
• Reduces excess production limit by divesting facilities
• Minimizes investments in capital-intensive facilities
• Improves net earnings and income
• Diverts resources to concentrate on different competencies like marketing

The report additionally states that outsourcing can permit pharmaceutical companies to establish consistency and proficiency across the sprawling supply chain, international networks of commercial, and manufacturing organizations and, whenever managed and executed strategically, can possibly add to shareholder value and keep the investment community happy. No small accomplishment in this time of economic turmoil.

Contract Manufacturing Market Size
The ever-increasing expenses of R&D combined with poor bottom lines and low productivity has constrained many pharmaceutical companies to outsource both research and development and manufacturing activities to low-cost nations, thereby saving expenses and time in the process. With increased activity in outsourcing, the worldwide market for such services has grown from roughly $57.2 billion in 2007 to an expected $76 billion this year. India, with a large share of US FDA-approved manufacturing facilities, is one of the most-liked locations for outsourcing manufacturing services.
Be that as it may, with outsourcing come concerns. Many pharmaceutical firms often managing long-distance and confused collaborative third-party relationships and afraid of losing control in proprietary knowledge and procedures, and delays because of regulatory hold-ups and imperfect processes.”

Certification
All Pharma Manufacturer must be WHO-GMP certified Manufacturer and few is WHO or equivalent Regulatory approved. One can’t hope to get 500 or 1000 boxes made from WHO-approved plants as there is not much statutory compliance that has to adhere, for small batches consider EU GMP certified Manufacturers.

Product Portfolio
Choosing a company with an extensive product portfolio is significant. Some Pharma Companies don’t offer a wide range of products which implies your rivals may have the edge over you and would have a superior possibility of converting a doctor. JoinHub Pharma provides over 1000 Products in different therapeutic segments which will help you in getting ahead of other PCD Pharma Companies.

Delivery
Maintaining the timeline is very important ordinarily it takes around 30-45 days for delivery of the first batch of products and on repeat order 30 days. Anyway, it might differ by not many days here and there. Kindly note the days referenced is after the design is approved not when the PO is raised.

Rates
It’s very hard to find the Manufacturer with lowest rates however for this it is suggested to contact multiple vendors to pick the best. Rates are directly proportionate to the Raw material which is fluctuating nowadays subsequently its advisable to place the order within 7 days of negotiations otherwise there are chances that when you will place the order the rates are changed because of the changes in the Raw material cost.

Agreement
Most of the Pharma contract manufacturer now requires an agreement with the marketing organization one regarding Trade name of the product, Marketing firms need to give an affidavit to the manufacturer that the Trade name of the brand under production has a place with the company and it reimburses the manufacturer in case of any trade name related issues.

Choosing a CMO
To discover more about the issues that face the industry when considering contract manufacturing, JoinHub Pharma recently finished a survey on “Choosing the Right Contract Manufacturer” We asked you, our readers, what particular qualities and capabilities you search for in a contract manufacturer. The survey results are printed here, yet some fascinating takeaways include:
• 60% of respondents intend to utilize the services of a CMO in the following year and a half.
• Particular product experience and cost were referred to as the two most significant CMO characteristics.
• Nearly 75% of all respondents would not hesitate to pick a CMO not based in their own nation.
• Expertise with a given application or service is the main explanation used to choose a CMO.
• Reputation is everything, and a poor reputation is the kiss of death for a CMO; FDA cautioning letters don’t help either.
• Confidentiality is significant. A history of being discrete with numerous customers is a prime CMO determination factor.
• With international regulatory agencies expanding their scrutiny on CMOs, respondents referred to finish cooperation during a recall as a significant CMO attribute.

These are a few factors that can assist you in choosing the Best Pharmaceutical Manufacturer in India. For more updates on pharma contract manufacturing company in India and how we can help you, please contact our team.

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