Each film-coated tablet contains Cefalexin monohydrate BP equivalent to anhydrous Phexin 375- and 750 mg, respectively.
It also contains the following excipients: Hyproellose, hydroxypropyl cellulose, microcrystalline cellulose, magnesium stearate, purified talc, colloidal anhydrous silica, opadry and macrogol 400.
Phexin is an extended release oral formulation of Phexin designed to be effective on twice daily dosing. Phexin is a semisynthetic cephalosporin antibiotic. It is 7-(D-α-Amino-α-phenylacetamido)-3-methyl-3-cephem-4-carboxylic acid monohydrate. Phexin has themolecular formula C16H17N3O4SH2O and the molecular weight is 365.41.
The nucleus of Phexin is related to that of other cephalosporin antibiotics. The compound is a zwitterion; ie, the molecule contains both a basic and an acidic group. The isoelectric point of Phexin in water is approximately 4.5-5. The crystalline form of Phexin which is available is a monohydrate. It is a white crystalline solid having a bitter taste. Solubility in water is low at room temperature; 1 or 2 mg/mL may be dissolved readily, but higher concentrations are obtained with increasing difficulty. The cephalosporins differ from penicillins in the structure of the bicyclic ring system. Phexin has a D-phenylglycyl group as substituent at the 7-amino position and an unsubstituted methyl group at the 3- position.
Prescription: Yes
Warnings: Do not take Phexin 250 Capsule 10's if you have porphyria (hereditary metabolic disorder). Before starting Phexin 250 Capsule 10's, please inform your doctor if you have any allergy (against any antibiotic), kidney or liver problems. Consult your doctor if you experience skin rash or prolonged, significant diarrhea with abdominal pains. Talk to your doctor before taking Phexin 250 Capsule 10's if you have/had inflammation of the intestine. Long-term usage of Phexin 250 Capsule 10's may lead to interaction with resistant bacteria and fungi. Avoid taking Phexin 250 Capsule 10's if you are pregnant or breastfeeding unless prescribed by a doctor. Phexin 250 Capsule 10's should not be given to children below 5 years.
Medicine Interaction: Phexin 250 Capsule 10's may have interaction with antibiotics (capreomycin, vancomycin, gentamicin, neomycin, tobramycin, cefuroxime), anti-fungal (amphotericin), anti-gout (probenecid), antidiabetic (metformin), and diuretics (furosemide, bumetanide).
Drug Schedule: Schedule H Prescription Drug
Side Effects: Adverse effects of Phexin include gastrointestinal disturbances eg, Nausea, vomiting, diarrhea and abdominal discomfort. The most common of these effects is diarrhea, but this is rarely severe enough to warrant cessation of therapy. Transient hepatitis and cholestatic jaundice have rarely been reported.
Allergic reactions have been reported eg, rash, urticaria, angioedema and rarely erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis (exanthematic necrolysis).
Other adverse effects eg, genital and anal pruritus, genital candidiasis, vaginitis and vaginal discharge, dizziness, fatigue, headache, agitation, confusion, hallucinations, arthralgia, arthritis and joint disorders have been reported.
As with other cephalosporins, interstitial nephritis has rarely been reported.
Eosinophilia, neutropenia, thrombocytopenia and slight elevations in aspartate aminotransferase and alanine aminotransferase have been reported.
As with other broad-spectrum antibiotics prolonged use may result in the overgrowth of non-susceptible organisms eg, candida. This may present a vulvo-vaginitis.
There is a possibility of development of pseudomembranous colitis and it is therefore important to consider its diagnosis in patients who develop diarrhea while taking Phexin. It may range in severity from mild to life-threatening with mild case usually responding to cessation of therapy. Appropriate measures should be taken with moderate to severe cases
How to Store it: Store Protected from light andmoisture, at a temperature not exceeding 30 C.
Over Dose: Store Protected from light andmoisture, at a temperature not exceeding 30 C.
Precautions: Store Protected from light andmoisture, at a temperature not exceeding 30 C.
Missed Dose: Store Protected from light andmoisture, at a temperature not exceeding 30 C.