JoinHub Pharma is a WHO-GMP & EU-GMP certified Ceftriaxone & Sulbactam Injection manufacturer, supplier & exporter based in India. JoinHub Pharma’s Ceftriaxone & Sulbactam Injection are GMP certified and are manufactured in our manufacturing facilities located in India.
We have a WHO-GMP manufacturing pharma factory located in Ahmedabad, Gujarat, India. According to international regulatory guidelines, the EUGMP-approved plant in India is built and also approved by WHO-GMP, EU-GMP, MOH of different countries, and other regulatory agencies.
Ceftriaxone & Sulbactam Injection
Therapy: Bacterial Infection
Active Ingredients: Ceftriaxone and Sulbactam
JoinHub Pharma is a popular manufacturer, supplier and exporter of Ceftriaxone & Sulbactam Injection in India.
Ceftriaxone+Sulbactam injection is essential to cure bacterial infections. This medication consists of Ceftriaxone and Sulbactam. Among these two ingredients, Ceftriaxone is a type of antibiotic. As an antibiotic, Ceftriaxone stops any bacterial growth from spreading further.
The usual side effects seen after administration of ceftriaxone injection include pain and swelling at the site where the injection is administered, skin rash, diarrhoea, nausea, vomiting and black stools. However, if any of these symptoms are persistent or if they worsen over the period of time, consult your healthcare provider immediately.
Indications and Usage:
The Ceftriaxone & Sulbactam Injection is usually prescribed for certain infections caused by Ceftriaxone sodium-sensitive pathogens. In terms of the clinical settings, this sulbactam injection is used in Sepsis, Meningitis, Abdominal Infections (e.g. Peritonitis, infection of the biliary tract), infections of the Bones, Joints, Soft tissue, wounds of the skin, Renal and Urinary Tract Infections, Respiratory tract Infections, particularly Pneumonia, and Ear, Nose and Throat Infections, and uncomplicated gonorrhoea. In addition to that, Ceftriaxone & Sulbactam for Injection may also be used for Perioperative Prophylaxis of
Infections. In terms of dosage, a single dose may be given before an operation. This is helpful in terms of avoiding any chances of complications arising in terms of infections Post Operation.
In order to prevent the risk of any development of bilirubin encephalopathy, use of Ceftriaxone & Sulbactam Injection is generally avoided especially in neonates in general and also prematures in particular. When the treatment of Ceftriaxone & Sulbactam Injection is prolonged for a certain period of time, the patient’s blood profile should be checked at regular intervals of time. Moreover, the dosage adjustments are usually not necessary in hepatic failure. However, in patients with hepatic dysfunction and significant renal malfunction, Ceftriaxone & Sulbactam Injection doses must maintain a limit. This limit
should not exceed an equivalent of 2g/day of Ceftriaxone. In fact, close serum monitoring is also an optimal option. The individuals who are sensitive to penicillin extreme caution needs to be exercised regularly. Those cases that show hypersensitivity reactions, should consider taking emergency measures like consulting your healthcare professional. When there is any allergic reaction, it usually means there is some interruption in the therapy of Ceftriaxone & Sulbactam Injection. Additionally, Ceftriaxone & Sulbactam Injection should not be administered to neonates in general, also hyperbilirubinemia neonates in particular, and to premature babies.
Administration and Dosage:
Your doctor will guide you accurately in terms of the dosage for lidocaine injection and one should not exceed it.
Over a period of time, there was no sight of impairment of renal function even after taking large doses of Ceftriaxone and potent diuretics. There is no information which supports that Ceftriaxone increases renal toxicity of aminoglycosides. Moreover, when The Ceftriaxone is eliminated, it is not altered by probenecid. Studies prove that Ceftriaxone and chloramphenicol are antagonistic in in vitro studies. When the case of concomitant severe renal and hepatic dysfunction arises, the plasma concentrations of
ceftriaxone should be determined at regular intervals. Remember that Coombs’ test may show false-positive results while undergoing Ceftriaxone therapy. Moreover, non-enzymatic urinary glucose estimation methods may also give false-positive results. In terms of reproductive studies of ceftriaxone have been performed in mice and rats at very high doses. As a result, no evidence of embryotoxicity, fetotoxicity or teratogenicity was observed. However, in absence of adequate and well-controlled studies in pregnant women, and since reproductive animal studies may not always show true human response, this drug should be used during pregnancy only if it is clearly needed. As ceftriaxone is secreted in the breast-milk, even though at a low concentration, caution should be exercised during its administration in nursing mothers.
As of now, very limited information is available on the acute toxicity of Ceftriaxone & Sulbactam Injection. Moreover, no specific antidote is available for treating overdose. In addition, Hemodialysis does not remove the drug from the system effectively. Hence, the treatment for Ceftriaxone & Sulbactam for Injection overdose is essentially supportive and symptomatic. Consult your healthcare expert immediately in the case of adverse reactions.
The following side effects are reported to occur during Ceftriaxone therapy and may be seen when it is administered with the combination as well. These reactions include- Gastrointestinal namely Diarrhoea, nausea & vomiting (less frequent), stomatitis, and glossitis. In terms of Hepatic, Elevations of SGOT/SGPT. While in the case it is Haematological, Eosinophilia, thrombocytopenia, leukopenia, granulocytopenia, hematoma or bleeding. However, Hemolytic anaemia is observed less frequently. Moreover, Agranulocytosis (< 500/mm 3) has been reported occasionally at a total cumulative dose exceeding 20 g. In terms of skin reactions, Exanthema, allergic dermatitis, pruritus, urticaria, edema, erythema multiforme is seen. Various other side effects such as headache, dizziness, increase in serum creatinine, mycosis of the genital tract, oliguria, fever, and shivering have been seen as well. In the case when Anaphylactic shock occurs, it will require immediate counter-measures. Some of the everyday reactions consisting of Pain, induration, and tenderness may be encountered in a small number of patients. But symptoms like inflammatory reactions in the vein wall may also occur after IV administration. These may
Be decreased by slow injection, given over the time duration of 2 to 5 minutes.