Xoclave DT Pharmaniaga is an antibiotic of group semisynthetic penicillins a wide spectrum of action. It is a 4-hydroxyl analog of ampicillin. It has bactericidal action. amoxicillin is Active against aerobic gram-positive bacteria: Staphylococcus spp. (except strains producing penicillinase), Streptococcus spp; aerobic gram-negative bacteria: Neisseria Gonorrhoeae, Neisseria Meningitidis, Escherichia Coli, Shigella spp. Salmonella spp. Klebsiella spp.
Microorganisms producing penicillinase is resistant to amoxicillin.
In combination with metronidazole Xoclave DT Pharmaniaga is Active against Helicobacter Pylori. It is believed that inhibits the development of amoxicillin resistance of Helicobacter pylori to metronidazole.
There is a cross-resistance between Xoclave DT and ampicillin.
The spectrum of antibacterial action while expanding the application of amoxicillin and beta-lactamase inhibitor clavulanic acid. This combination increased the Activity of amoxicillin against Bacteroides spp. Legionella spp. Nocardia spp. Pseudomonas (Burkholderia) Pseudomallei. However, Pseudomonas Aeruginosa, Serratia Marcescens, and many other gram-bacteria are resistant.
Prescription: Yes
Medicine Interaction: If you use other drugs or over the counter products at the same time, the effects of Xoclave 228.5 DT Tablet may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Xoclave 228.5 DT Tablet may interact with the following drugs and products:
Allopurinol
Chloramphenicol
Macrolides
Oral contraceptives
Probenecid
Sulfonamides
Tetracyclines
Drug Schedule: Schedule H Prescription Drug
Side Effects: Allergic reactions: urticaria, erythema, edema Quincke, rhinitis, conjunctivitis, rarely - fever, joint pain, eosinophilia, in rare cases - anaphylactic shock.
Side effects associated with chemotherapy effect: possible development of super-infection (particularly in patients with chronic diseases or low resistance of the organism).
With prolonged use at high doses: dizziness, ataxia, confusion, depression, peripheral neuropathy, seizures.
Mostly when Xoclave DT Pharmaniaga used in combination with metronidazole: Nausea, vomiting, anorexia, diarrhea, constipation, epigastric pain, glossitis, stomatitis, rarely - hepatitis, pseudomembranous colitis, allergic reactions (urticaria, angioedema), interstitial nephritis, a violation of hematopoiesis.
Mostly when Xoclave DT Pharmaniaga used in combination with clavulanic acid: cholestatic jaundice, hepatitis, rarely - erythema multiforme, toxic epidermal necrolysis, exfoliative dermatitis.
